This paper makes comparative analysis on risks in varied routes of currency invoicing and relationships between different routes and economic targets. Moreover, the prospect of cross-border trade invoicing in RMB has been predicted on the ground of comparative analysis on determinant factors about internationalization of RMB and Yen in respective period. The conclusion has shown that trade invoicing in RMB has been superior to Yen’s internationalization in the aspects of market share in trade and stability of exchange rate, while underdeveloped trade structure has been its disadvantage. The current pattern of “export mainly invoicing in foreign currency while import mainly invoicing in RMB” does not benefit to hedging risk on firms, reducing trade surplus, promoting trade structure, and it will cause new problem of obligatory right in RMB abroad which creates external constraint on monetary policy. However, it should not been changed in current situation. The focus should be promoting quality of export commodities in order to coordinate the relationships between routes of currency invoicing and economic targets. Consequently, cross-border trade invoicing in RMB can be upgraded from single-pattern leading to multi-pattern interacting.