Manufacturing of potential competitive advantage and investment is strong positive correlation. The main method to measure the investment is industry capital deepening analysis. Based on the Yangtze river delta and the Pearl river delta manufacturing industry as the research region, the two regions have formed the manufacturing clusters, which using the composite location identify. It analyzes the capital deepening trend of 20 manufacturing clusters. It also analyzes the effect of manufacturing clusters capital deepening based on two aspects of increasing return of capital and capital return rate. The conclusions on manufacturing capital deepening effect and trend analysis may be used for decision-making reference for relative administrative departments to adjust the industrial structure.