Regional trade agreements can be divided into two main “families” of agreements, GATS-type and NAFTA-type agreements. Although the number of GATS-type has not decreased, the number of NAFTA-type grows more quickly. That is because “list or lose” nature of negative-list determines that NAFTA-type is more liberalized. Regional trade agreements, especially the NAFTA-type agreements, have extended negotiating issues to “21st century agenda” which relates to domestic regulatory regimes. It suggests that the main concern domains of developed economies have moved from seeking market-opening to coordinating regulatory regimes, or means for them to export their regulatory regimes to developing countries, so as to further promote liberalization of trade in services.