The manufacturing innovation institute which is found by American government is a new innovation mechanism for addressing the new industrial revolution, it put governments, industries and academia together for achieving Leapfrog innovation in advanced manufacturing technology. Its core functions are developing new technologies, educating and training new workforce, and forming a sustainable business model, and connecting the institutes into a network amplifies their impact on advanced manufacturing and benefitting the entire nation. Among this, the government endeavor but not offside: overcoming market failure on pre-competitive development of technology, remedying the shortage of enterprise, supervising innovative performance and ensuring to come true the expected goals. All of this is reference for “establish manufacturing innovation centre” which is presented in made in China 2025.