Using trade friction data from 31 countries in 2006-2014, the paper empirically tested the impact ofeconomic cycle and economic policy uncertainty on trade friction. The results show that the downward trend ofthe economy has significantly increased the scale of trade friction; The economic policy uncertainty of the hostcountry and the home country is positively related to trade friction, and the host country is positively related toeconomic policy uncertainty and trade friction, indicating that the host country is the "leader" of trade frictionwith China. Based on the above conclusions, this paper makes suggestions on how to deal with the externalmarket environment, reduce uncertainty, resolve trade disputes, improve trade quality, and build win-wineconomic and trade relations.