The global economy has officially entered “great change” phase, marked by the launch of the “301 Survey” by the United States against China in early 2018. At this stage, “rebalancing” of global economic, the reconstruction of global trade rules, and the widening of the globalization gap of the digital economy will appear for a long time. China's external environment for opening up to the outside world has also changed: 1. The adjustment of global supply chain and production layout are speeding up; 2. Mutual beneficial concession models for economies with different market structures is constructing; 3. The digital economic globalization order is becoming more complex. For this, China put forward a new strategy of opening up to the outside world, that is, “to accelerate a new development pattern with a domestic cycle as the main body and a domestic and international dual cycle mutual promotion”. The proposal of this new strategy urgently requires us to make a series of responses to the “great changes” of the global economy, including: 1. Being prepare to shift from “trade war” to “rule war”; 2. Breaking through the bottleneck of factor price market reform as soon as possible; 3. Making due contributions to bridging the globalization gap of the digital economy.