The original negotiation of international economic and trade rules mainly focused on the border measures of various countries. However, with the development of multilateral trade system, border measures are no longer the main form of trade barriers, behind-the-border measures with domestic regulation as the main content have gradually become new obstacles to the trade liberalization. In practice, behind-the-border measures are likely to be used as a hidden means of trade protection, and their formation is often hijacked by interest groups. Therefore, in order to avoid the behind-the-border measures being hijacked by interest groups becoming new barriers to trade liberalization, countries should actively promote international regulatory cooperation to regulate behind-the-border measures. At present, the international regulatory cooperation of behind-the-border measures has gone through the development process from "negative integration" to "positive integration", from "shallow integration" to "deep integration", and from the multilateral level to the regional level, showing a combination of various forms. In addition to the transfer of economic sovereignty, the core issues of current international regulatory cooperation also involve transparency and platform selection. Therefore, in the process of international regulatory cooperation, countries should pay attention to balancing economic sovereignty and regulatory cooperation, improving transparency, and try to use open plurilateral agreements as a new platform for international regulatory cooperation. While international regulatory cooperation is increasingly becoming the focus of international economic and trade negotiations, there are some problems in China, such as low transparency of regulatory system, inconsistency between central and local regulation, low participation in international standardization and low degree of regulatory cooperation in FTAs. In order to play a leading role in the new round of international economic and trade negotiations, China should pay attention to international regulatory cooperation, deepen the reform of domestic regulatory system, and actively participate in international regulatory cooperation.