After the reactivation of the Appellate Body, the normalized operation of WTO Appellate Arbitration would have a far-reaching impact on the WTO Dispute Settlement Mechanism. According to the interpretation provisions of the Vienna Convention on the Law of Treaties, as an alternative dispute settlement method, the arbitration under Article 25 of DSU has the legal effect of substituting the appellate review procedure, which provides a legal basis for the normalized operation of WTO Appellate Arbitration. WTO Appellate Arbitration meets the institutional needs of the WTO Dispute Settlement Mechanism to prevent the risk of failing again and pursue a higher level of development, which is of positive significance for the reform of the WTO Dispute Settlement Mechanism, thus the normalized operation of WTO Appellate Arbitration is reasonable. In the process of promoting the normalized operation of WTO Appellate Arbitration in the future, it is necessary to clarify the parallel procedural and substantive coordination relationship between the Appellate Arbitration and the Appellate Review Procedure, and properly address a number of issues that need to be considered for the normalized operation of WTO Appellate Arbitration, which includes the employment of arbitrators and arbitration secretaries, the financing and allocation of funds, the formulation of model procedural rules, and the strict guarantee of the consistency of awards.