In the era of the digital economy, architectural innovation has become a strategic imperative for enterprises to compete in the market. However, the relationship between product architecture and organizational architecture has gradually shifted from a mirroring relationship to a more nebulous and decoupled confi guration. To promote co-evolutionary innovation in duallayer architectures, this study integrates Chandler’s strategy-structure theory, core competence theory, and sensemaking theory, with a focus on the synergy between digital technology orientation (DTO) and organizational mindfulness (OM). It develops an antecedent model for product architectural innovation and organizational architectural innovation. Using questionnaire data from 683 manufacturing enterprises, polynomial regression and response surface analysis were employed to empirically test the hypotheses. Key fi ndings include: Both DTO and OM positively infl uence dual-layer architectural innovation(product architectural innovation and organizational architectural innovation). When DTO and OM are aligned, the “high-high” alignment exerts stronger positive eff ects on product architectural innovation and organizational architectural innovation than the “low-low” alignment. When DTO and OM are misaligned, the “high DTO-low OM” confi guration demonstrates greater positive impacts on product architectural innovation and organizational architectural innovation than the “low DTO-high OM” confi guration. Dynamic capabilities partially mediate the synergistic relationship between DTO-OM alignment and dual-layer architectural innovation. This research enriches strategic choice theory and strategy implementation theory in explaining architectural innovation. It off ers actionable insights for enterprises to manage product and organizational architectural innovation in dynamic environments.