The "Chain Leaders" have the leading ability of cross-border supply chain. The supply chain rules can motivate the "Chain Leaders" to protect national security and stimulate the global governance potential of the private sector. However, improper regulation will lead to the "Chain Leaders" blindly implementing the behavior of "chain breaking and restructuring" and distorting the international economic and trade order. Using the typological analysis method, the legal regulation of "Chain Leaders" can be divided into four categories: forbidden type, controversial type, sensitive type and harmless type, so as to clarify the boundary of legitimacy with "discrimination" as the standard. China can absorb the experience of "Chain Leaders" regulation of local policies, give full play to the professional advantages of "Chain Leaders" and promote the legalization of its rights and obligations: take harmless regulation as the focus, realize the harmlessness of controversial regulation, strengthen the counter measures of prohibited regulation, and carry out sensitive regulation under the guidance of the principle of goodwill, so as to make China's contribution to the global governance of supply chain.